| First Author | Shin SY | Year | 2013 |
| Journal | Biochim Biophys Acta | Volume | 1829 |
| Issue | 10 | Pages | 1066-74 |
| PubMed ID | 23872552 | Mgi Jnum | J:210058 |
| Mgi Id | MGI:5569452 | Doi | 10.1016/j.bbagrm.2013.07.005 |
| Citation | Shin SY, et al. (2013) Transcriptional regulation of the growth-regulated oncogene alpha gene by early growth response protein-1 in response to tumor necrosis factor alpha stimulation. Biochim Biophys Acta 1829(10):1066-74 |
| abstractText | Growth-regulated oncogene alpha (GROalpha) plays an important role in a wide range of normal and pathological conditions, including inflammation, angiogenesis, wound healing, tumor invasion, and metastasis. Egr-1 is a member of the zinc-finger transcription factor family induced by diverse stimuli, including TNFalpha. However, the role of Egr-1 in GROalpha expression was previously unknown. This study shows that Egr-1 directly binds to the GROalpha promoter and transactivates the GROalpha gene. Silencing of Egr-1 by expression of Egr-1 siRNA abrogated TNFalpha-induced GROalpha transcription. We also found that Egr-1 mediates ERK and JNK MAPK-dependent GROalpha transcription upon TNFalpha stimulation. Our findings suggest that Egr-1 may play an important role in tumor development through transactivation of the GROalpha gene in response to TNFalpha within the tumor microenvironment. |
