| First Author | Beltran H | Year | 2014 |
| Journal | Mol Cancer Res | Volume | 12 |
| Issue | 6 | Pages | 815-22 |
| PubMed ID | 24589438 | Mgi Jnum | J:211570 |
| Mgi Id | MGI:5575690 | Doi | 10.1158/1541-7786.MCR-13-0536 |
| Citation | Beltran H (2014) The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential. Mol Cancer Res 12(6):815-22 |
| abstractText | N-myc (MYCN), a member of the Myc family of basic-helix-loop-helix-zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well recognized for its classic oncogenic activity and association with human neuroblastoma. Amplification and overexpression of N-myc has been described in other tumor types, particularly those of neural origin and neuroendocrine tumors. This review outlines N-myc's contribution to normal development and oncogenic progression. In addition, it highlights relevant transcriptional targets and mechanisms of regulation. Finally, the clinical implications of N-Myc as a biomarker and potential as a target using novel therapeutic approaches are discussed. |
