| First Author | Yan-nan B | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 443 |
| Issue | 3 | Pages | 802-7 |
| PubMed ID | 24342610 | Mgi Jnum | J:211855 |
| Mgi Id | MGI:5576812 | Doi | 10.1016/j.bbrc.2013.12.047 |
| Citation | Yan-nan B, et al. (2014) MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN. Biochem Biophys Res Commun 443(3):802-7 |
| abstractText | MicroRNAs (miRNAs) are involved in controlling hepatocyte proliferation during liver regeneration. In this study, we established the miRNAs-expression patterns of primary hepatocytes in vitro under stimulation of epidermal growth factor (EGF), and found that microRNA-21 (miR-21) was appreciably up-regulated and peaked at 12h. In addition, we further presented evidences indicating that miR-21 promotes primary hepatocyte proliferation through in vitro transfecting with miR-21 mimics or inhibitor. We further demonstrated that phosphatidylinositol 3'-OH kinase (PI3K)/Akt signaling was altered accordingly, it is, by targeting phosphatase and tensin homologue deleted on chromosome 10, PI3K/Akt signaling is activated by miR-21 to accelerate hepatocyte rapid S-phase entry and proliferation in vitro. |
