| First Author | Fort A | Year | 2014 |
| Journal | Nat Genet | Volume | 46 |
| Issue | 6 | Pages | 558-66 |
| PubMed ID | 24777452 | Mgi Jnum | J:212321 |
| Mgi Id | MGI:5578660 | Doi | 10.1038/ng.2965 |
| Citation | Fort A, et al. (2014) Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance. Nat Genet 46(6):558-66 |
| abstractText | The importance of microRNAs and long noncoding RNAs in the regulation of pluripotency has been documented; however, the noncoding components of stem cell gene networks remain largely unknown. Here we investigate the role of noncoding RNAs in the pluripotent state, with particular emphasis on nuclear and retrotransposon-derived transcripts. We have performed deep profiling of the nuclear and cytoplasmic transcriptomes of human and mouse stem cells, identifying a class of previously undetected stem cell-specific transcripts. We show that long terminal repeat (LTR)-derived transcripts contribute extensively to the complexity of the stem cell nuclear transcriptome. Some LTR-derived transcripts are associated with enhancer regions and are likely to be involved in the maintenance of pluripotency. |
