| First Author | Namba T | Year | 2014 |
| Journal | Neuron | Volume | 81 |
| Issue | 4 | Pages | 814-29 |
| PubMed ID | 24559674 | Mgi Jnum | J:213066 |
| Mgi Id | MGI:5582845 | Doi | 10.1016/j.neuron.2013.12.015 |
| Citation | Namba T, et al. (2014) Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron 81(4):814-29 |
| abstractText | The polarization of neurons, which mainly includes the differentiation of axons and dendrites, is regulated by cell-autonomous and non-cell-autonomous factors. In the developing central nervous system, neuronal development occurs in a heterogeneous environment that also comprises extracellular matrices, radial glial cells, and neurons. Although many cell-autonomous factors that affect neuronal polarization have been identified, the microenvironmental cues involved in neuronal polarization remain largely unknown. Here, we show that neuronal polarization occurs in a microenvironment in the lower intermediate zone, where the cell adhesion molecule transient axonal glycoprotein-1 (TAG-1) is expressed in cortical efferent axons. The immature neurites of multipolar cells closely contact TAG-1-positive axons and generate axons. Inhibition of TAG-1-mediated cell-to-cell interaction or its downstream kinase Lyn impairs neuronal polarization. These results show that the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1. |
