| First Author | Fujii Y | Year | 2013 |
| Journal | Genes Cells | Volume | 18 |
| Issue | 2 | Pages | 79-89 |
| PubMed ID | 23331702 | Mgi Jnum | J:214927 |
| Mgi Id | MGI:5604215 | Doi | 10.1111/gtc.12024 |
| Citation | Fujii Y, et al. (2013) IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells. Genes Cells 18(2):79-89 |
| abstractText | Neural precursor cells (NPCs) in the mammalian neocortex generate various neuronal and glial cell types in a developmental stage-dependent manner. Most neocortical NPCs lose their neurogenic potential after birth. We have previously shown that high-mobility group A (HMGA) proteins confer the neurogenic potential on early-stage NPCs during the midgestation period, although the underlying mechanisms are not fully understood. In this study, we found that HMGA2 promotes the expression of insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, Igf2bp2) in neocortical NPCs. The level of IMP2 was indeed high in early-stage NPCs compared with that in late-stage NPCs. Importantly, over-expression of IMP2 increased the neurogenic potential and suppressed astrocytic differentiation of late-stage NPCs, whereas knockdown of IMP2 promoted astrocytic differentiation and reduced the neurogenic potential of early-stage neocortical NPCs without overtly affecting cell proliferation. Our results thus identified IMP2 as a developmental stage-dependent regulator of the differentiation potentials of NPCs in the mouse neocortex. |
