| First Author | Mossmann D | Year | 2014 |
| Journal | Cell Metab | Volume | 20 |
| Issue | 4 | Pages | 662-9 |
| PubMed ID | 25176146 | Mgi Jnum | J:215558 |
| Mgi Id | MGI:5605622 | Doi | 10.1016/j.cmet.2014.07.024 |
| Citation | Mossmann D, et al. (2014) Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab 20(4):662-9 |
| abstractText | Most mitochondrial proteins possess N-terminal presequences that are required for targeting and import into the organelle. Upon import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (Abeta). Here we find that impaired turnover of presequence peptides results in feedback inhibition of presequence processing enzymes. Moreover, Abeta inhibits degradation of presequence peptides by PreP, resulting in accumulation of mitochondrial preproteins and processing intermediates. Dysfunctional preprotein maturation leads to rapid protein degradation and an imbalanced organellar proteome. Our findings reveal a general mechanism by which Abeta peptide can induce the multiple diverse mitochondrial dysfunctions accompanying Alzheimer's disease. |
