| First Author | Lee II | Year | 2014 |
| Journal | Biol Reprod | Volume | 91 |
| Issue | 3 | Pages | 63 |
| PubMed ID | 25100707 | Mgi Jnum | J:215749 |
| Mgi Id | MGI:5606209 | Doi | 10.1095/biolreprod.114.119255 |
| Citation | Lee II, et al. (2014) Influence of AKT on progesterone action in endometrial diseases. Biol Reprod 91(3):63 |
| abstractText | Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer. |
