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Publication : SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

First Author	Ramirez A	Year	2014
Journal	Hum Mol Genet	Volume	23
Issue	24	Pages	6644-58
PubMed ID	25027320	Mgi Jnum	J:216197
Mgi Id	MGI:5607853	Doi	10.1093/hmg/ddu372
Citation	Ramirez A, et al. (2014) SUCLG2 identified as both a determinator of CSF Abeta1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Hum Mol Genet 23(24):6644-58

abstractText

Cerebrospinal fluid amyloid-beta 1-42 (Abeta1-42) and phosphorylated Tau at position 181 (pTau181) are biomarkers of Alzheimer's disease (AD). We performed an analysis and meta-analysis of genome-wide association study data on Abeta1-42 and pTau181 in AD dementia patients followed by independent replication. An association was found between Abeta1-42 level and a single-nucleotide polymorphism in SUCLG2 (rs62256378) (P = 2.5x10(-12)). An interaction between APOE genotype and rs62256378 was detected (P = 9.5 x 10(-5)), with the strongest effect being observed in APOE-epsilon4 noncarriers. Clinically, rs62256378 was associated with rate of cognitive decline in AD dementia patients (P = 3.1 x 10(-3)). Functional microglia experiments showed that SUCLG2 was involved in clearance of Abeta1-42.

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39 Authors

Cruchaga C,
Nöthen MM,
Ramonet D,
Louwersheimer E,
Kummer MP,
Breteler MM,
Peters O,
Chouraki V,
Teunissen C,
Goate A,
Hüll M,
International Genomics of Alzheimer's Project (IGAP).,
Scheltens P,
Hoffmann P,
Heneka MT,
Naj AC,
Heun R,
Heilmann S,
Wiltfang J,
van der Flier WM,
Frölich L,
Maier W,
Buscemi L,
Herold C,
Lacour A,
Becker T,
Kölsch H,
Gerrish A,
Kornhuber J,
Popp J,
Jessen F,
Herms S,
Drichel D,
Alzheimer's Disease Neuroimaging Initiative (ADNI).,
Holstege H,
Ramirez A,
Bellenguez C,
Lewczuk P,
Rüther E

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