| First Author | Jhaveri DJ | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 6 | Pages | e98736 |
| PubMed ID | 24922313 | Mgi Jnum | J:217322 |
| Mgi Id | MGI:5613753 | Doi | 10.1371/journal.pone.0098736 |
| Citation | Jhaveri DJ, et al. (2014) Opposing effects of alpha2- and beta-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. PLoS One 9(6):e98736 |
| abstractText | Norepinephrine regulates latent neural stem cell activity and adult hippocampal neurogenesis, and has an important role in modulating hippocampal functions such as learning, memory and mood. Adult hippocampal neurogenesis is a multi-stage process, spanning from the activation and proliferation of hippocampal stem cells, to their differentiation into neurons. However, the stage-specific effects of noradrenergic receptors in regulating adult hippocampal neurogenesis remain poorly understood. In this study, we used transgenic Nestin-GFP mice and neurosphere assays to show that modulation of alpha2- and beta-adrenergic receptor activity directly affects Nestin-GFP/GFAP-positive precursor cell population albeit in an opposing fashion. While selective stimulation of alpha2-adrenergic receptors decreases precursor cell activation, proliferation and immature neuron number, stimulation of beta-adrenergic receptors activates the quiescent precursor pool and enhances their proliferation in the adult hippocampus. Furthermore, our data indicate no major role for alpha1-adrenergic receptors, as we did not observe any change in either the activation and proliferation of hippocampal precursors following selective stimulation or blockade of alpha1-adrenergic receptors. Taken together, our data suggest that under physiological as well as under conditions that lead to enhanced norepinephrine release, the balance between alpha2- and beta-adrenergic receptor activity regulates precursor cell activity and hippocampal neurogenesis. |
