First Author | Souroullas GP | Year | 2015 |
Journal | Cancer Cell | Volume | 27 |
Issue | 1 | Pages | 3-5 |
PubMed ID | 25584887 | Mgi Jnum | J:218896 |
Mgi Id | MGI:5619006 | Doi | 10.1016/j.ccell.2014.12.005 |
Citation | Souroullas GP, et al. (2015) mTOR signaling in melanoma: oncogene-induced pseudo-senescence?. Cancer Cell 27(1):3-5 |
abstractText | Oncogene-induced senescence (OIS) is thought to be a barrier to malignant transformation resulting from the strong activation of oncogenes. In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations. |