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Publication : mTOR signaling in melanoma: oncogene-induced pseudo-senescence?

First Author  Souroullas GP Year  2015
Journal  Cancer Cell Volume  27
Issue  1 Pages  3-5
PubMed ID  25584887 Mgi Jnum  J:218896
Mgi Id  MGI:5619006 Doi  10.1016/j.ccell.2014.12.005
Citation  Souroullas GP, et al. (2015) mTOR signaling in melanoma: oncogene-induced pseudo-senescence?. Cancer Cell 27(1):3-5
abstractText  Oncogene-induced senescence (OIS) is thought to be a barrier to malignant transformation resulting from the strong activation of oncogenes. In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
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