| First Author | Deng P | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 458 |
| Issue | 1 | Pages | 123-7 |
| PubMed ID | 25637537 | Mgi Jnum | J:220327 |
| Mgi Id | MGI:5634224 | Doi | 10.1016/j.bbrc.2015.01.080 |
| Citation | Deng P, et al. (2015) Cysteine dioxygenase type 1 promotes adipogenesis via interaction with peroxisome proliferator-activated receptor gamma. Biochem Biophys Res Commun 458(1):123-7 |
| abstractText | Mammalian cysteine dioxygenase type 1 (CDO1) is an essential enzyme for taurine biosynthesis and the biodegradation of toxic cysteine. As previously suggested, Cdo1 may be a marker of liposarcoma progression and adipogenic differentiation, but the role of Cdo1 in adipogenesis has yet been reported. In this study, we found that the expression of Cdo1 is dramatically elevated during adipogenic differentiation of 3T3-L1 pre-adipocytes and mouse bone marrow-derived mesenchymal stem cells (mBMSCs). Conversely, knockdown of Cdo1 inhibited expression of adipogenic specific genes and lipid droplet formation in 3T3-L1 cells and mBMSCs. Mechanistically, we found Cdo1 interacted with Ppargamma in response to adipogenic stimulus. Further, depletion of Cdo1 reduced the recruitment of Ppargamma to the promoters of C/EBPalpha and Fabp4. Collectively, our finding indicates that Cdo1 may be a co-activator of Ppargamma in adipogenesis, and may contribute to the development of disease associated with excessive adipose tissue. |
