| First Author | Zhong L | Year | 2015 |
| Journal | J Neurosci | Volume | 35 |
| Issue | 19 | Pages | 7503-8 |
| PubMed ID | 25972176 | Mgi Jnum | J:221636 |
| Mgi Id | MGI:5641262 | Doi | 10.1523/JNEUROSCI.0274-15.2015 |
| Citation | Zhong L, et al. (2015) Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. J Neurosci 35(19):7503-8 |
| abstractText | Increasing plasticity in neurons of the prefrontal cortex (PFC) has been proposed as a possible therapeutic tool to enhance extinction, a process that is impaired in post-traumatic stress disorder, schizophrenia, and addiction. To test this hypothesis, we generated transgenic mice that overexpress neurogranin (a calmodulin-binding protein that facilitates long-term potentiation) in the PFC. Neurogranin overexpression in the PFC enhanced long-term potentiation and increased the rates of extinction learning of both fear conditioning and sucrose self-administration. Our results indicate that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. Thus, neurogranin can provide a molecular link between enhanced plasticity and enhanced extinction. |
