| First Author | Krawczyk MC | Year | 2015 |
| Journal | Neuroscience | Volume | 294 |
| Pages | 227-37 | PubMed ID | 25791227 |
| Mgi Jnum | J:222278 | Mgi Id | MGI:5644221 |
| Doi | 10.1016/j.neuroscience.2015.03.019 | Citation | Krawczyk MC, et al. (2015) Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation. Neuroscience 294:227-37 |
| abstractText | Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15 min after memory reactivation, and an inhibition at 45 min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40 min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. |
