| First Author | Duensing A | Year | 2015 |
| Journal | Cancer Discov | Volume | 5 |
| Issue | 3 | Pages | 231-3 |
| PubMed ID | 25749973 | Mgi Jnum | J:222590 |
| Mgi Id | MGI:5644905 | Doi | 10.1158/2159-8290.CD-15-0116 |
| Citation | Duensing A (2015) Targeting ETV1 in gastrointestinal stromal tumors: tripping the circuit breaker in GIST?. Cancer Discov 5(3):231-3 |
| abstractText | Activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes are the key oncogenic drivers in the majority of gastrointestinal stromal tumors (GIST), but novel results now show that aberrant kinase signaling is potentiated by a positive feedback circuit that involves the ETS transcription factor ETV1. Targeting ETV1 can disrupt this circuit and represents a promising new therapeutic approach for the treatment of GISTs. |
