| First Author | Yu H | Year | 2015 |
| Journal | J Neurochem | Volume | 135 |
| Issue | 2 | Pages | 261-73 |
| PubMed ID | 26178610 | Mgi Jnum | J:226076 |
| Mgi Id | MGI:5695731 | Doi | 10.1111/jnc.13238 |
| Citation | Yu H, et al. (2015) Headless Myo10 is a regulator of microtubule stability during neuronal development. J Neurochem 135(2):261-73 |
| abstractText | Stabilized microtubules are required for neuronal morphogenesis and migration. However, the underlying mechanism is not fully understood. In this study, we demonstrate that myosin X (Myo10), which is composed of full-length myosin X (fMyo10) and headless myosin X (hMyo10), is important for axon development. fMyo10 is involved in axon elongation, whereas hMyo10 is critical for Tau-1 positive axon formation through stabilizing microtubules. Furthermore, in vivo studies reveal that hMyo10-mediated microtubule stability has a profound effect on both neuronal migration and dendritic arborization in the mammalian cerebral cortex. Taken together, our findings suggest that hMyo10 is involved in neuronal development both in vitro and in vivo by regulating microtubule stability. In this study, we demonstrate that headless myosin X (hMyo10) is involved in microtubule stability regulation, which is important for neuronal morphogenesis and migration. In vitro studies reveal that hMyo10 regulates Tau-1 positive axon formation through stabilizing microtubules. Furthermore, in vivo studies reveal that hMyo10-mediated microtubule stability has a profound effect on radial cortical neuronal migration and apical dendritic arborization. |
