| First Author | Kim DH | Year | 2015 |
| Journal | Neuroscience | Volume | 310 |
| Pages | 51-62 | PubMed ID | 26363149 |
| Mgi Jnum | J:227504 | Mgi Id | MGI:5700603 |
| Doi | 10.1016/j.neuroscience.2015.09.017 | Citation | Kim DH, et al. (2015) Peptide fragment of thymosin beta4 increases hippocampal neurogenesis and facilitates spatial memory. Neuroscience 310:51-62 |
| abstractText | Although several studies have suggested the neuroprotective effect of thymosin beta4 (TB4), a major actin-sequestering protein, on the central nervous system, little is understood regarding the action of N-acetyl-serylaspartyl-lysyl-proline (Ac-SDKP), a peptide fragment of TB4 on brain function. Here, we examined neurogenesis-stimulative effect of Ac-SDKP. Intrahippocampal infusion of Ac-SDKP facilitated the generation of new neurons in the hippocampus. Ac-SDKP-treated mouse hippocampus showed an increase in beta-catenin stability with reduction of glycogen synthase kinase-3beta (GSK-3beta) activity. Moreover, inhibition of vascular endothelial growth factor (VEGF) signaling blocked Ac-SDKP-facilitated neural proliferation. Subchronic intrahippocampal infusion of Ac-SDKP also increased spatial memory. Taken together, these data demonstrate that Ac-SDKP functions as a regulator of neural proliferation and indicate that Ac-SDKP may be a therapeutic candidate for diseases characterized by neuronal loss. |
