| First Author | Wier EM | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 23 | Pages | 3581-7 |
| PubMed ID | 26526615 | Mgi Jnum | J:228081 |
| Mgi Id | MGI:5705189 | Doi | 10.1016/j.febslet.2015.10.019 |
| Citation | Wier EM, et al. (2015) Caspase-3 cleaved p65 fragment dampens NF-kappaB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction. FEBS Lett 589(23):3581-7 |
| abstractText | Caspase-3-mediated p65 cleavage is believed to suppress nuclear factor-kappa B (NF-kappaB)-mediated anti-apoptotic transactivation in cells undergoing apoptosis. However, only a small percentage of p65 is cleaved during apoptosis, not in proportion to the dramatic reduction in NF-kappaB transactivation. Here we show that the p65(1-97) fragment generated by Caspase-3 cleavage interferes with ribosomal protein S3 (RPS3), an NF-kappaB "specifier" subunit, and selectively retards the nuclear translocation of RPS3, thus dampening the RPS3/NF-kappaB-dependent anti-apoptotic gene expression. Our findings reveal a novel cell fate determination mechanism to ensure cells undergo programed cell death through interfering with RPS3/NF-kappaB-conferred anti-apoptotic transcription by the fragment from partial p65 cleavage by activated Caspase-3. |
