| First Author | Yang AN | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 24 Pt B | Pages | 3998-4009 |
| PubMed ID | 26606905 | Mgi Jnum | J:228208 |
| Mgi Id | MGI:5705670 | Doi | 10.1016/j.febslet.2015.11.010 |
| Citation | Yang AN, et al. (2015) High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice. FEBS Lett 589(24 Pt B):3998-4009 |
| abstractText | Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy on fatty acid-binding protein 4 (FABP4), and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased FABP4 expression and decreased methylation. The FABP4 expression and DNA methylation was assessed in the aorta of ApoE(-/-) mice fed high-methionine diet for 20weeks. Over-expression of FABP4 enhanced accumulation of total cholesterol and cholesterol ester in foam cells. The up-regulation of DNA methyltransferase 1 (DNMT1) promoted the methylation process and decreased FABP4 expression. These data suggest that FABP4 plays a key role in Hcy-mediated disturbance of lipid metabolism and that DNMT1 may be a novel therapeutic target in Hcy-related atherosclerosis. |
