|  Help  |  About  |  Contact Us

Publication : Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

First Author  Grasso CS Year  2015
Journal  Nat Med Volume  21
Issue  6 Pages  555-9
PubMed ID  25939062 Mgi Jnum  J:228469
Mgi Id  MGI:5707127 Doi  10.1038/nm.3855
Citation  Grasso CS, et al. (2015) Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med 21(6):555-9
abstractText  Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

0 Bio Entities

0 Expression