| First Author | Grasso CS | Year | 2015 |
| Journal | Nat Med | Volume | 21 |
| Issue | 6 | Pages | 555-9 |
| PubMed ID | 25939062 | Mgi Jnum | J:228469 |
| Mgi Id | MGI:5707127 | Doi | 10.1038/nm.3855 |
| Citation | Grasso CS, et al. (2015) Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med 21(6):555-9 |
| abstractText | Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG. |
