| First Author | Yu Q | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 464 |
| Issue | 2 | Pages | 447-52 |
| PubMed ID | 26145601 | Mgi Jnum | J:228655 |
| Mgi Id | MGI:5708431 | Doi | 10.1016/j.bbrc.2015.06.135 |
| Citation | Yu Q, et al. (2015) Stromal cell-derived factor-1 alpha alleviates hypoxic-ischemic brain damage in mice. Biochem Biophys Res Commun 464(2):447-52 |
| abstractText | Hypoxic-ischemic brain damage (HIBD) is a major cause of acute deaths and chronic nervous system damage. There is good evidence that stromal cell-derived factor-1 alpha (SDF-1alpha) has been receiving much interest in its role in the treatment of ischemic diseases. Here we aim to investigate the effect of intraperitoneal delivery of SDF-1alpha after experimental hypoxia-ischemia (HI) and the potentially involved mechanisms. A total of 129 mice were subjected to unilateral carotid artery ligation followed by 2.5 h of hypoxia, randomly assigned to three groups: sham, HI + vehicle and HI + SDF-1alpha. Mice treated with SDF-1alpha showed recovery of spatial learning abilities and pathological conditions, decreased number of apoptotic cells, and elevated expression of SDF-1alpha and its cognate receptor, CXC chemokine receptor-4 (CXCR4). Meanwhile, the increased number of mesenchymal stem cells (MSCs) was found in peripheral blood after SDF-1alpha treatment. Taken together, the treatment of SDF-1alpha after HIBD contributed to an improved functional recovery, and this behavioral restoration was paralleled by a reduction of apoptosis and mobilization of MSCs via SDF-1alpha/CXCR4. |
