| First Author | Martín V | Year | 2016 |
| Journal | J Virol | Volume | 90 |
| Issue | 7 | Pages | 3783-8 |
| PubMed ID | 26739058 | Mgi Jnum | J:230507 |
| Mgi Id | MGI:5762730 | Doi | 10.1128/JVI.03258-15 |
| Citation | Martin V, et al. (2016) A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice. J Virol 90(7):3783-8 |
| abstractText | Ovine interferon tau (IFN-tau) is a unique type I interferon with low toxicity and a broad host range in vivo. We report the generation of a nonreplicative recombinant adenovirus expressing biologically active IFN-tau. Using the B6.A2G-Mx1 mouse model, we showed that single-dose intranasal administration of recombinant Ad5-IFN-tau can effectively prevent lethality and disease induced by highly virulent hv-PR8 influenza virus by activating the interferon response and preventing viral replication. |
