| First Author | Wang Y | Year | 2015 |
| Journal | Mol Immunol | Volume | 65 |
| Issue | 2 | Pages | 224-9 |
| PubMed ID | 25700345 | Mgi Jnum | J:231499 |
| Mgi Id | MGI:5771640 | Doi | 10.1016/j.molimm.2015.01.012 |
| Citation | Wang Y, et al. (2015) TRAF6 is required for the GM-CSF-induced JNK, p38 and Akt activation. Mol Immunol 65(2):224-9 |
| abstractText | JNK, p38 and Akt signalings have been shown to be activated by granulocyte-macrophage colony-stimulating factor (GM-CSF) and are pivotal for GM-CSF-mediated survival, proliferation and differentiation of macrophages and their progenitors. However, the detailed mechanism of how these signalings is activated by GM-CSF is not fully elucidated. We report here that E3 ligase TRAF6 is required for the GM-CSF-induced activation of JNK, p38 and Akt. GM-CSF triggers autoubiquitination of TRAF6 and TRAF6 knocked down results in impaired activation of JNK and p38 signaling. TRAF6 is also required for GM-CSF-induced ubiquitination and activation of Akt. These findings reveal novel roles of TRAF6 in GM-CSF signaling. |
