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Publication : CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER²⁺ Breast Cancer.

First Author  Malumbres M Year  2016
Journal  Cancer Cell Volume  29
Issue  3 Pages  243-4
PubMed ID  26977873 Mgi Jnum  J:231768
Mgi Id  MGI:5774906 Doi  10.1016/j.ccell.2016.02.016
Citation  Malumbres M (2016) CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER2(+) Breast Cancer. Cancer Cell 29(3):243-4
abstractText  CDK4/6 inhibitors have received approval for treating hormone-positive breast tumors, but whether other aggressive cancers respond to these molecules is not yet clear. In this issue of Cancer Cell, Goel et al. (2016) report an unexpected activity of CDK4/6 inhibitors in reducing mTOR function and re-sensitizing HER2-positive cancers to EGFR/HER2 blockade.
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