| First Author | Pham K | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 8 | Pages | 1114-22 |
| PubMed ID | 27009418 | Mgi Jnum | J:232127 |
| Mgi Id | MGI:5776081 | Doi | 10.1002/1873-3468.12156 |
| Citation | Pham K, et al. (2016) Molecular insight of DREAM and presenilin 1 C-terminal fragment interactions. FEBS Lett 590(8):1114-22 |
| abstractText | Interactions between downstream regulatory element antagonist modulator (DREAM) and presenilin 1 (PS1) are related to numerous neuronal processes. We demonstrate that association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 and F252 from DREAM. Additional stabilization is provided by residues in a loop connecting alpha helices 7 and 8 in DREAM and residues of PS1, namely cation-pi interactions between R200 in DREAM and F465 in PS1 and the salt bridges formed by R207 in DREAM and D450 and D458 in PS1. |
