| First Author | Guo C | Year | 2015 |
| Journal | Mol Immunol | Volume | 67 |
| Issue | 2 Pt B | Pages | 436-43 |
| PubMed ID | 26239416 | Mgi Jnum | J:233098 |
| Mgi Id | MGI:5780778 | Doi | 10.1016/j.molimm.2015.07.009 |
| Citation | Guo C, et al. (2015) IL-23, rather than IL-17, is crucial for the development of ovalbumin-induced allergic rhinitis. Mol Immunol 67(2 Pt B):436-43 |
| abstractText | Interleukin-23 (IL-23) and IL-17 are involved in the pathogenesis of allergic rhinitis (AR). However, the roles of IL-23 and IL-17 in ovalbumin (OVA)-induced AR remain unclear. Therefore in this study we aim to investigate the precise roles of IL-23 and IL-17 in a mouse model of OVA-induced AR. We found that during OVA-induced AR, eosinophil and goblet cells in the nose were significantly decreased in IL-23-deficient, but not in IL-17-deficient mice. However, there was no difference in the serum IgE and IgG1 levels between IL-23-deficient or IL-17-deficient and wild-type mice. Moreover, IL-4 levels in lymph node cell culture supernatants were significantly decreased in IL-23-deficient, but not IL-17-deficient, compared with wild-type mice. Furthermore, OVA-induced AR developed similarly in wild-type mice transferred with either IL-23-deficient BM cells or wild-type BM cells. These findings suggest that IL-23, but not IL-17 is crucial for the development of OVA-induced AR, and IL-23 neutralization may be a potential approach for treatment of OVA-induced AR in humans. |
