| First Author | Tesio M | Year | 2016 |
| Journal | Oncogene | Volume | 35 |
| Issue | 30 | Pages | 3887-96 |
| PubMed ID | 26616857 | Mgi Jnum | J:234380 |
| Mgi Id | MGI:5789861 | Doi | 10.1038/onc.2015.462 |
| Citation | Tesio M, et al. (2016) Oncogenic PTEN functions and models in T-cell malignancies. Oncogene 35(30):3887-96 |
| abstractText | PTEN is a protein phosphatase that is crucial to prevent the malignant transformation of T-cells. Although a numerous mechanisms regulate its expression and function, they are often altered in T-cell acute lymphoblastic leukaemias and T-cell lymphomas. As such, PTEN inactivation frequently occurs in these malignancies, where it can be associated with chemotherapy resistance and poor prognosis. Different Pten knockout models recapitulated the development of T-cell leukaemia/lymphoma, demonstrating that PTEN loss is at the center of a complex oncogenic network that sustains and drives tumorigenesis via the activation of multiple signalling pathways. These aspects and their therapeutic implications are discussed in this review. |
