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Publication : Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development.

First Author  Zeisig BB Year  2016
Journal  Cancer Cell Volume  30
Issue  2 Pages  185-187
PubMed ID  27505665 Mgi Jnum  J:234910
Mgi Id  MGI:5792431 Doi  10.1016/j.ccell.2016.07.014
Citation  Zeisig BB, et al. (2016) Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development. Cancer Cell 30(2):185-7
abstractText  Polycomb repressive complexes (PRCs) are key to normal development and are frequently deregulated in human cancer. In this issue of Cancer Cell, Beguelin et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration with EZH2-mediated H3K27me3 for establishment of stable repressive complexes in germinal center B cells.
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