| First Author | Zhao G | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 17 | Pages | 2884-95 |
| PubMed ID | 27434861 | Mgi Jnum | J:235139 |
| Mgi Id | MGI:5792980 | Doi | 10.1002/1873-3468.12315 |
| Citation | Zhao G, et al. (2016) The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-kappaB. FEBS Lett 590(17):2884-95 |
| abstractText | MALAT1 is a conserved long noncoding RNA whose expression correlates with many human cancers. However, its significance in immunity remains largely unknown. Here, we observe that MALAT1 is upregulated in lipopolysaccharide (LPS)-activated macrophages. Knockdown of MALAT1 increases LPS-induced expression of TNFalpha and IL-6. Mechanistically, MALAT1 was found to interact with NF-kappaB in the nucleus, thus inhibiting its DNA binding activity and consequently decreasing the production of inflammatory cytokines. Additionally, abnormal expression of MALAT1 was found to be NF-kappaB-dependent. These findings suggest that MALAT1 may function as an autonegative feedback regulator of NF-kappaB to help fine-tune innate immune responses. |
