| First Author | Chien CY | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 477 |
| Issue | 4 | Pages | 874-880 |
| PubMed ID | 27381866 | Mgi Jnum | J:238682 |
| Mgi Id | MGI:5823347 | Doi | 10.1016/j.bbrc.2016.06.151 |
| Citation | Chien CY, et al. (2016) All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A. Biochem Biophys Res Commun 477(4):874-80 |
| abstractText | Patients with type 1 diabetes mellitus are associated with impairment in vitamin A metabolism. This study evaluated whether treatment with retinoic acid, the biologically active metabolite of vitamin A, can ameliorate diabetes. All-trans retinoic acid (atRA) was used to treat streptozotocin (STZ)-induced diabetic mice which revealed atRA administration ameliorated blood glucose levels of diabetic mice. This hyperglycemic amelioration was accompanied by an increase in the amount of beta cells co-expressed Pdx1 and insulin and by restoration of the vascular laminin expression. The atRA-induced production of vascular endothelial growth factor-A from the pancreatic islets was possibly the key factor that mediated the restoration of islet vascularity and recovery of beta-cell mass. Furthermore, the combination of islet transplantation and atRA administration significantly rescued hyperglycemia in diabetic mice. These findings suggest that vitamin A derivatives can potentially be used as a supplementary treatment to improve diabetes management and glycemic control. |
