| First Author | Liu M | Year | 2024 |
| Journal | Cancer Cell | Volume | 42 |
| Issue | 11 | Pages | 1820-1822 |
| PubMed ID | 39423815 | Mgi Jnum | J:358051 |
| Mgi Id | MGI:7779257 | Doi | 10.1016/j.ccell.2024.09.015 |
| Citation | Liu M, et al. (2024) IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled. Cancer Cell |
| abstractText | In a Science paper, Park et al. identified interleukin (IL)-1alpha as a key driver of positive feedback in inflammaging, linking aging-associated downregulation of DNMT3A to increased IL-1alpha production in lung myeloid cells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice. |
