| First Author | Case LK | Year | 2012 |
| Journal | G3 (Bethesda) | Volume | 2 |
| Issue | 1 | Pages | 115-21 |
| PubMed ID | 22384388 | Mgi Jnum | J:244970 |
| Mgi Id | MGI:5913749 | Doi | 10.1534/g3.111.001610 |
| Citation | Case LK, et al. (2012) Chromosome y regulates survival following murine coxsackievirus b3 infection. G3 (Bethesda) 2(1):115-21 |
| abstractText | Coxsackievirus B3 (CVB3) contributes to the development of myocarditis, an inflammatory heart disease that predominates in males, and infection is a cause of unexpected death in young individuals. Although gonadal hormones contribute significantly to sex differences, sex chromosomes may also influence disease. Increasing evidence indicates that Chromosome Y (ChrY) genetic variants can impact biological functions unrelated to sexual differentiation. Using C57BL/6J (B6)-ChrY consomic mice, we show that genetic variation in ChrY has a direct effect on the survival of CVB3-infected animals. This effect is not due to potential Sry-mediated differences in prenatal testosterone exposure or to differences in adult testosterone levels. Furthermore, we show that ChrY polymorphism influences the percentage of natural killer T cells in B6-ChrY consomic strains but does not underlie CVB3-induced mortality. These data underscore the importance of investigating not only the hormonal regulation but also ChrY genetic regulation of cardiovascular disease and other male-dominant, sexually dimorphic diseases and phenotypes. |
