| First Author | Swaroop A | Year | 2010 |
| Journal | Nat Rev Neurosci | Volume | 11 |
| Issue | 8 | Pages | 563-76 |
| PubMed ID | 20648062 | Mgi Jnum | J:243109 |
| Mgi Id | MGI:5907601 | Doi | 10.1038/nrn2880 |
| Citation | Swaroop A, et al. (2010) Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina. Nat Rev Neurosci 11(8):563-76 |
| abstractText | In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell fate determination, with the S cone representing the default state of a generic photoreceptor precursor. Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment of neurodegenerative diseases. |
