| First Author | Godinho-Silva C | Year | 2014 |
| Journal | PLoS Pathog | Volume | 10 |
| Issue | 6 | Pages | e1004220 |
| PubMed ID | 24967892 | Mgi Jnum | J:245542 |
| Mgi Id | MGI:5916063 | Doi | 10.1371/journal.ppat.1004220 |
| Citation | Godinho-Silva C, et al. (2014) Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation. PLoS Pathog 10(6):e1004220 |
| abstractText | Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for gamma-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition remain poorly defined. We used Murid Herpesvirus-4 (MuHV-4) to determine for a latently expressed viral epitope how MHC class-I binding and CTL functional avidity impact on host colonization. Tracking MuHV-4 recombinants that differed only in epitope presentation, we found little latitude for sub-optimal MHC class I binding before immune control failed. By contrast, control remained effective across a wide range of T cell functional avidities. Thus, we could define critical engagement thresholds for the in vivo immune control of virus-driven B cell proliferation. |
