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Publication : Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice.

First Author  Jianhua F Year  2017
Journal  Behav Brain Res Volume  316
Pages  136-144 PubMed ID  27609644
Mgi Jnum  J:249170 Mgi Id  MGI:5921977
Doi  10.1016/j.bbr.2016.09.011 Citation  Jianhua F, et al. (2017) Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice. Behav Brain Res 316:136-144
abstractText  It is well known that social defeat stress can induce depressive behaviours and cognitive impairment. However, the molecular mechanism by which only a minority of stress-exposed individuals are affected is not clear. In this study, thirty 3-week-old male c57BL/6 mice were exposed to 30 days of social defeat stress, following which susceptible (socially avoidant) and unsusceptible (socially interactive) mice were identified using social investigation. Twenty-four hours after the last episode of defeat, separate groups of mice were tested in the sucrose preference, open field, elevated plus-maze and Morris water maze behavioural assays. Also, the levels of memory-associated proteins in the hippocampus were examined, including postsynaptic density 95 (PSD95), postsynaptic density 93 (PSD93), and Protein kinase A (PKA). The levels of PSD95, PSD93, and PKA were significantly lower in susceptible mice. We also found that the upstream regulatory factor of these proteins, phosphorylated Camp-Responsive Element-Binding Protein (CREB), was reduced after social defeat in the susceptible group only, while the level of histone deacetylase 6 (HDAC6) was significantly elevated. These data suggest that memory-associated proteins and phosphorylated CREB may play important roles in memory impairment and behavioural responses to chronic stress.
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