| First Author | Meghnem D | Year | 2017 |
| Journal | J Immunol | Volume | 198 |
| Issue | 12 | Pages | 4563-4568 |
| PubMed ID | 28507024 | Mgi Jnum | J:247738 |
| Mgi Id | MGI:5926200 | Doi | 10.4049/jimmunol.1700046 |
| Citation | Meghnem D, et al. (2017) Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rbeta/gammac Receptor. J Immunol 198(12):4563-4568 |
| abstractText | Interleukin 2 and IL-15 are two closely related cytokines, displaying important functions in the immune system. They share the heterodimeric CD122/CD132 receptor to deliver their signals within target cells. Their specificity of action is conferred by their alpha receptor chains, IL-2Ralpha and IL-15Ralpha. By combining an increased affinity for CD122 and an impaired recruitment of CD132, we have generated an original molecule named IL-2Rbeta/gamma (CD122/CD132) inhibitor (BiG), targeting the CD122/CD132 receptor. BiG efficiently inhibited IL-15- and IL-2-dependent functions of primary cells, including CD8 T and NK cells, in vitro and in vivo. We also report a differential dynamic of action of these cytokines by highlighting a major role played by the IL-2Ralpha receptor. Interestingly, due to the presence of IL-2Ralpha, BiG had no impact on IL-2-dependent regulatory T cell proliferation. Thus, by acting as a fine switch in the immune system, BiG emphasizes the differential roles of these two cytokines. |
