| First Author | Porras DP | Year | 2017 |
| Journal | Stem Cells | Volume | 35 |
| Issue | 5 | Pages | 1378-1391 |
| PubMed ID | 28233396 | Mgi Jnum | J:255156 |
| Mgi Id | MGI:6093093 | Doi | 10.1002/stem.2576 |
| Citation | Porras DP, et al. (2017) p107 Determines a Metabolic Checkpoint Required for Adipocyte Lineage Fates. Stem Cells 35(5):1378-1391 |
| abstractText | We show that the transcriptional corepressor p107 orchestrates a metabolic checkpoint that determines adipocyte lineage fates for non-committed progenitors. p107 accomplishes this when stem cell commitment would normally occur in growth arrested cells. p107-deficient embryonic progenitors are characterized by a metabolic state resembling aerobic glycolysis that is necessary for their pro-thermogenic fate. Indeed, during growth arrest they have a reduced capacity for NADH partitioning between the cytoplasm and mitochondria. Intriguingly, this occurred despite an increase in the capacity for mitochondrial oxidation of non-glucose substrates. The significance of metabolic reprogramming is underscored by the disruption of glycolytic capacities in p107-depleted progenitors that reverted their fates from pro-thermogenic to white adipocytes. Moreover, the manipulation of glycolytic capacity on nonspecified embryonic and adult progenitors forced their beige fat commitment. These innovative findings introduce a new approach to increase pro-thermogenic adipocytes based on simply promoting aerobic glycolysis to manipulate nonspecified progenitor fate decisions. Stem Cells 2017;35:1378-1391. |
