| First Author | Pulikkan JA | Year | 2017 |
| Journal | Leukemia | Volume | 31 |
| Issue | 11 | Pages | 2279-2285 |
| PubMed ID | 28720765 | Mgi Jnum | J:249419 |
| Mgi Id | MGI:6093836 | Doi | 10.1038/leu.2017.229 |
| Citation | Pulikkan JA, et al. (2017) C/EBPalpha deregulation as a paradigm for leukemogenesis. Leukemia 31(11):2279-2285 |
| abstractText | Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBPalpha) is deregulated by multiple mechanisms in leukemia. Inhibition of C/EBPalpha function plays pivotal roles in leukemogenesis. While much is known about how C/EBPalpha orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPalpha deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBPA mutations. We conclude by describing emerging therapeutic strategies to restore C/EBPalpha function. |
