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Publication : PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

First Author	Meehan TF	Year	2017
Journal	Cancer Res	Volume	77
Issue	21	Pages	e62-e66
PubMed ID	29092942	Mgi Jnum	J:249366
Mgi Id	MGI:6094135	Doi	10.1158/0008-5472.CAN-17-0582
Citation	Meehan TF, et al. (2017) PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res 77(21):e62-e66

abstractText

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. (c)2017 AACR.

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Publication : PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

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