| First Author | Buus TB | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Issue | 1 | Pages | 1911 |
| PubMed ID | 29203769 | Mgi Jnum | J:257663 |
| Mgi Id | MGI:6112558 | Doi | 10.1038/s41467-017-01963-w |
| Citation | Buus TB, et al. (2017) Three distinct developmental pathways for adaptive and two IFN-gamma-producing gammadelta T subsets in adult thymus. Nat Commun 8(1):1911 |
| abstractText | Murine gammadelta T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different gammadelta T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of gammadelta T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRdelta repertoires and exhibit characteristic expression patterns associated with adaptive (gammadeltaTn), IFN-gamma-producing (gammadeltaT1) and IFN-gamma/IL-4-co-producing gammadelta T cells (gammadeltaNKT). Developmental progression towards both IFN-gamma-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that gammadeltaT1 cells are the predominating IFN-gamma-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of gammadeltaTn, gammadeltaT1 and gammadeltaNKT cells. |
