| First Author | Sun HM | Year | 2017 |
| Journal | J Immunol | Volume | 199 |
| Issue | 5 | Pages | 1817-1826 |
| PubMed ID | 28739877 | Mgi Jnum | J:251079 |
| Mgi Id | MGI:6100180 | Doi | 10.4049/jimmunol.1602018 |
| Citation | Sun HM, et al. (2017) PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization. J Immunol 199(5):1817-1826 |
| abstractText | PALLD is an actin cross-linker supporting cellular mechanical tension. However, its involvement in the regulation of phagocytosis, a cellular activity essential for innate immunity and physiological tissue turnover, is unclear. We report that PALLD is highly induced along with all-trans-retinoic acid-induced maturation of myeloid leukemia cells, to promote Ig- or complement-opsonized phagocytosis. PALLD mechanistically facilitates phagocytic receptor clustering by regulating actin polymerization and c-Src dynamic activation during particle binding and early phagosome formation. PALLD is also required at the nascent phagosome to recruit phosphatase oculocerebrorenal syndrome of Lowe, which regulates phosphatidylinositol-4,5-bisphosphate hydrolysis and actin depolymerization to complete phagosome closure. Collectively, our results show a new function for PALLD as a crucial regulator of the early phase of phagocytosis by elaborating dynamic actin polymerization and depolymerization. |
