| First Author | Luo J | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 485 |
| Issue | 3 | Pages | 577-583 |
| PubMed ID | 27923659 | Mgi Jnum | J:251046 |
| Mgi Id | MGI:6102774 | Doi | 10.1016/j.bbrc.2016.12.022 |
| Citation | Luo J, et al. (2017) Matrilin-2 regulates proliferation, apoptosis and cell cycle during radiation-induced injury in HPAEpiC cell. Biochem Biophys Res Commun 485(3):577-583 |
| abstractText | Radiation pulmonary injury is related to the accumulation of extracellular matrix proteins in the alveolar interstitial space. Matrilin-2 as a component of extracellular filamentous networks, present higher level in the lung tissue from irradiated mice and irradiated pulmonary epithelial cell line, HPAEpiC cells. Knockdown of endogenous matrilin-2 prevents the apoptosis of HPAEpiC cell induced by the irradiation injury. Consistently, over-expression of matrilin-2 reduced the proliferation and induced apoptosis of HPAEpiC cells. Matrilin-2 promotes the expression of p21 via increasing the transcriptional activity of p53, by which induces the G1 phase arresting in HPAEpiC cells. In summary, matrilin-2, increased by irradiation, reduced the proliferation and induces apoptosis of pulmonary epithelial cells via p53/p21 pathway. |
