| First Author | Sumaria N | Year | 2017 |
| Journal | Cell Rep | Volume | 19 |
| Issue | 12 | Pages | 2469-2476 |
| PubMed ID | 28636936 | Mgi Jnum | J:254704 |
| Mgi Id | MGI:6103702 | Doi | 10.1016/j.celrep.2017.05.071 |
| Citation | Sumaria N, et al. (2017) Strong TCRgammadelta Signaling Prohibits Thymic Development of IL-17A-Secreting gammadelta T Cells. Cell Rep 19(12):2469-2476 |
| abstractText | Despite a growing appreciation of gammadelta T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two distinct developmental pathways that generate gammadelta T cells pre-committed to subsequent secretion of either IL-17A or IFNgamma. Importantly, this framework for tracking gammadelta T cell development has permitted definitive assessment of TCRgammadelta signal strength in commitment to gammadelta T cell effector fate; increased TCRgammadelta signal strength profoundly prohibited the development of all IL-17A-secreting gammadelta T cells, regardless of Vgamma usage, but promoted the development of gammadelta progenitors along the IFNgamma pathway. This clarifies the recently debated role of TCRgammadelta signal strength in commitment to distinct gammadelta T cell effector fates and proposes an alternate methodology for the study of gammadelta T cell development. |
