| First Author | Goupille O | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 12 | Pages | 3524-3535 |
| PubMed ID | 29262331 | Mgi Jnum | J:255915 |
| Mgi Id | MGI:6104997 | Doi | 10.1016/j.celrep.2017.11.098 |
| Citation | Goupille O, et al. (2017) The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis. Cell Rep 21(12):3524-3535 |
| abstractText | GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown fat conversion. Thus, each component of the GATA/FOG complex (GATA-1 and FOG-2) is involved in pRb/E2F regulation, but these molecules have markedly different roles in the control of tissue homeostasis. |
