| First Author | Veselits M | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 12 | Pages | 3775-3790 |
| PubMed ID | 29141870 | Mgi Jnum | J:251936 |
| Mgi Id | MGI:6106599 | Doi | 10.1084/jem.20161868 |
| Citation | Veselits M, et al. (2017) Igbeta ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med 214(12):3775-3790 |
| abstractText | A wealth of in vitro data has demonstrated a central role for receptor ubiquitination in endocytic sorting. However, how receptor ubiquitination functions in vivo is poorly understood. Herein, we report that ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals. These signals are necessary and sufficient for accumulating phosphatidylinositol (3,4,5)-trisphosphate (PIP3) on B cell receptor-containing early endosomes and proper sorting into the MHC class II antigen-presenting compartment (MIIC). Surprisingly, MIIC targeting is dispensable for T cell-dependent immunity. Rather, it is critical for activating endosomal toll-like receptors and antiviral humoral immunity. These findings demonstrate a novel mechanism of receptor endosomal signaling required for specific peripheral immune responses. |
