| First Author | Wang LW | Year | 2017 |
| Journal | J Virol | Volume | 91 |
| Issue | 21 | PubMed ID | 28835489 |
| Mgi Jnum | J:256433 | Mgi Id | MGI:6108401 |
| Doi | 10.1128/JVI.01718-16 | Citation | Wang LW, et al. (2017) Epstein-Barr Virus LMP1-Mediated Oncogenicity. J Virol 91(21) |
| abstractText | Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-kappaB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches. |
