| First Author | Wang J | Year | 2017 |
| Journal | FASEB J | Volume | 31 |
| Issue | 11 | Pages | 4959-4970 |
| PubMed ID | 28754714 | Mgi Jnum | J:253393 |
| Mgi Id | MGI:6108592 | Doi | 10.1096/fj.201700093R |
| Citation | Wang J, et al. (2017) NRF1 coordinates with DNA methylation to regulate spermatogenesis. FASEB J 31(11):4959-4970 |
| abstractText | Spermatogenesis is a highly coordinated process that requires tightly regulated gene expression programmed by transcription factors and epigenetic modifiers. In this study, we found that nuclear respiratory factor (NRF)-1, a key transcription factor for mitochondrial biogenesis, cooperated with DNA methylation to directly regulate the expression of multiple germ cell-specific genes, including Asz1 In addition, conditional ablation of NRF1 in gonocytes dramatically down-regulated these germline genes, blocked germ cell proliferation, and subsequently led to male infertility in mice. Our data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis.-Wang, J., Tang, C., Wang, Q., Su, J., Ni, T., Yang, W., Wang, Y., Chen, W., Liu, X., Wang, S., Zhang, J., Song, H., Zhu, J., Wang, Y. NRF1 coordinates with DNA methylation to regulate spermatogenesis. |
