| First Author | Nakahashi-Oda C | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 4 | Pages | 441-50 |
| PubMed ID | 26855029 | Mgi Jnum | J:283005 |
| Mgi Id | MGI:6141195 | Doi | 10.1038/ni.3345 |
| Citation | Nakahashi-Oda C, et al. (2016) Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nat Immunol 17(4):441-50 |
| abstractText | Epithelial tissues continually undergo apoptosis. Commensal organisms that inhabit the epithelium influence tissue homeostasis, in which regulatory T cells (Treg cells) have a central role. However, the physiological importance of epithelial cell apoptosis and how the number of Treg cells is regulated are both incompletely understood. Here we found that apoptotic epithelial cells negatively regulated the commensal-stimulated proliferation of Treg cells. Gut commensals stimulated CX3CR1(+)CD103(-)CD11b(+) dendritic cells (DCs) to produce interferon-beta (IFN-beta), which augmented the proliferation of Treg cells in the intestine. Conversely, phosphatidylserine exposed on apoptotic epithelial cells suppressed IFN-beta production by the DCs via inhibitory signaling mediated by the cell-surface glycoprotein CD300a and thus suppressed Treg cell proliferation. Our findings reveal a regulatory role for apoptotic epithelial cells in maintaining the number of Treg cell and tissue homeostasis. |
