| First Author | Sun G | Year | 2018 |
| Journal | J Exp Med | Volume | 215 |
| Issue | 2 | Pages | 521-535 |
| PubMed ID | 29282251 | Mgi Jnum | J:257688 |
| Mgi Id | MGI:6120026 | Doi | 10.1084/jem.20170686 |
| Citation | Sun G, et al. (2018) gammadelta T cells provide the early source of IFN-gamma to aggravate lesions in spinal cord injury. J Exp Med 215(2):521-535 |
| abstractText | Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). gammadelta T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in gammadelta T cells (TCRdelta(-/-) ) showed improved functional recovery after SCI. gammadelta T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the Vgamma4 subtype and express the inflammatory cytokine IFN-gamma. Inactivating IFN-gamma signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-Vgamma4 antibodies has a beneficial effect, similar to that obtained with anti-TNF-alpha. In SCI patients, gammadelta T cells are detected in the CSF, and most of them are IFN-gamma positive. In conclusion, manipulation of gammadelta T cell functions may be a potential approach for future SCI treatment. |
